קטיה גרייצר

תלמידת המחלקה לתואר שני תרצה בנושא:

Intravascular Blood Volume Estimation during Fluid Resuscitation

Hemorrhagic shock, caused by a massive loss of blood, is one of the leading causes of death in the battlefield and other trauma events. Fluid resuscitation of the trauma victim is a fundamental part of hemorrhagic shock therapy. Its primary objective is to restore the function of the cardiovascular system by restoring the circulating vascular volume. Whole blood transfusion as well as plasma transfusion are the best replacement therapy, but not available on field conditions. Various plasma substitutes have been developed in order to deal with these circumstances, mostly crystalloid solutions (isotonic and hypotonic solutions). One of the major disadvantages of these solutions is that they have only transient effect on the intravascular volume because of their migration to the extravascular compartments as well. Another issue that should be concerned is the dangerous of causing edema because of the fluid partitioning between the intravascular and the extravascular compartments. Therefore, there is a need for a method to determine the changes in blood volume during the fluid therapy procedure, after hemorrhage of an unknown volume followed by a known volume of infusion. A number of mathematical models have developed over the past years that address the issue of body fluid distribution after fluid resuscitation. For the current research, a lumped model of the cardiovascular system including an interstitium compartment was developed. The model was used to simulate the effects of fluid infusion on the hemodynamic variables and the redistribution of fluid between intravascular and extravascular compartments after hemorrhagic shock, with the particular goal of describing blood volume changes that follow hemorrhage. Based on the model an algorithm was developed to estimate intravascular blood volume based on hematocrit dilution. Model predictions were compared with animal experiments. Once non invasive hematocrit measurement devices are available, this method could be applicable in the prehospital setting.

העבודה נעשתה בהנחייתו של פרופ'  עופר ברנע, המחלקה להנדסה ביו-רפואית,

אוניברסיטת תל-אביב

ההרצאה תתקיים ביום ראשון 17.6.2012, בשעה 14:45,

בחדר 315, הבניין הרב תחומי, אוניברסיטת תל אביב