MEA technology is a
powerful platform employed for in-vitro and in-vivo neuronal applications.
While used very extensively, some of the details associated with MEA recordings
are not entirely understood. In this project we have used a new setup combining
MEA recording with Ca imaging to reveal the true nature of the technique. In
particular, we explored MEA recordings in-vitro using low-density dissociated
neurons.
Figure 1: Neurons
cultured on a micro electrode
Nitzan Herzog, Mark Shein, Yael
Hanein, Optical validation of in-vitro extra-cellular neuronal recordings,
Journal of Neural Engineering, In press 2011.