MEA Technology

 

MEA technology is a powerful platform employed for in-vitro and in-vivo neuronal applications. While used very extensively, some of the details associated with MEA recordings are not entirely understood. In this project we have used a new setup combining MEA recording with Ca imaging to reveal the true nature of the technique. In particular, we explored MEA recordings in-vitro using low-density dissociated neurons.

 

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Figure 1: Neurons cultured on a micro electrode

 

 

Nitzan Herzog, Mark Shein, Yael Hanein, Optical validation of in-vitro extra-cellular neuronal recordings, Journal of Neural Engineering, In press 2011.