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Journal of Microwave Power
and Electromagnetic Energy (JMPEE) |
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TITLE |
The Minimum Inactivated Cell Ratio: A Concept for the Estimation
of Biological Effectiveness of Hyperthermic
Treatment of Tissue [PDF] |
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AUTHORS |
H.G.
Klinger 1979 14 2 151-154 |
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Abstract The experimental conditions
used to investigate the dose-effect relationships for hyperthermic
treatment of cells in vitro cannot be realized in vivo. Thus it is not possible
to predict the cell inactivation due to a hyperthermic
treatment of the tissue in vivo, using the in vitro dose
effect-relationships. However, the in vitro dose-effect curves in combination
with the temperature field in vivo make it possible to calculate the lower
limit of the biological effect, the minimum inactivated cell ratio (MIR).
This magnitude is of clinical relevance. The present paper gives the
algorithm for the calculation of the MIR, and discusses the influence of the
heat supply time on the local biological effect for a model with spherical
symmetry. |
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