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Journal of Microwave Power
and Electromagnetic Energy (JMPEE) |
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TITLE |
Local Hyperthermia
and Irradiation in Cancer Therapy [PDF] |
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AUTHORS |
1981 16 2 205-214 |
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Abstract The preliminary
experience at the Mallinekrodt Institute of
Radiology with hyperthermia and irradiation is reported and current issues in
clinical application of heat are reviewed. Twenty-nine lesions were treated
with 400 rad fractions every 72 h (twice weekly)
for a total dose of 2400 to 4000 rad followed by
hyperthermia (2450-MHz or 915-MHz microwaves, 42.0º -43°, 90 min, every 72
h). Eight of 12 recurrent epidermoid carcinomas of
the head and neck showed complete regression (67%) and one more than 50%
response. Of 5 metastatic melanoma nodules treated
with irradiation and hyperthermia, 4 (80%) showed complete regression of the tumors and 1 almost complete response. Of
9 recurrent adenocarcinoma of breast nodules in the
chest wall treated with 3200 to 4000 rad 5
lesions exhibited complete regression and 2 others about 80%. Of 6 lesions
treated with 1500 rad and hyperthermia (RTOG
protocol), 2 metastatic melanomas showed complete
regression (CR) and 3 tumors exhibited partial
regression. Of the 35 sites treated, 4 (11%) developed blisters, 7 (20%) erythema only, 3 (8%) moist desquamation and 27 (77%) dry
desquamation. Additional clinical trials are in progress to assess the
potential value of hyperthermia alone or combined with irradiation in the
treatment of selected cancer patients. |
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