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Journal of Microwave Power
and Electromagnetic Energy (JMPEE) |
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TITLE |
Study of a Microwave
Assisted Vacuum Drying Process Applied to the Granulated Pharmaceutical Drug Hydrochlorthiazide (HCT) [PDF] |
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AUTHORS |
M. N. Berteli,
A. Marsaioli, Jr. and E. Rodier 2005 40 4 241- |
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Abstract Drying processes have evolved
considerably over the years, aiming at the best conditions to shorten the
processing time, but maintaining the highest final product quality. The
application of vacuums to the microwave drying process might be interesting,
especially for thermally sensitive products because the reduced boiling point
of the solvent allows a lower temperature processing. The objective of the
present work is to study and evaluate the process of drying a granulated
product that is the basis of the drug hydrochlorthiazide,
with an initial moisture content of 21% in dry basis. This study monitored
the drying kinetics, product temperature and power absorbed by the sample
using a bench scale vacuum microwave dryer. The equipment consisted of a
cylindrical pressure vessel crossed by a wave guide, setting up a system
whereby the vacuum pressure, the sample weight and the incident, reflected
and residual microwave powers could be measured and evaluated, throughout the
entire process. The experimental runs were established with an approximate
incident microwave power at 20 W for absolute pressure levels of 50 and 75 mbar,
working with samples of about |
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