If you're driving, take the "Rokach" exit on the Ayalon, and follow the signs up a steep hill to the university. Bear right at the first round-about, and go north. Park in the first guest parking lot on your left. If you reach a second round-about and Gate 14, it means you missed the parking lot: turn around and go back. The signs at the parking lot say "George Wise East" and also "Avoda Socialit / Kitot Hashmal". The building is right behind that parking lot.
If you're walking/cycling from the exact sciences buildings, cross the foot-bridge south of the exact sciences library and continue south past the grey wall of the old Wolfson building. Once you see a colonnade start on your left, go up a short flight of stairs, cross through the colonnade, and continue diagonally and uphill (going south-east) for some 50m. At the top you will reach the north side of Wolfson Software Engineering building: Either use the side door, or continue around the corner of the building (now going south) to the main entrance.
Here is a map (or in English) of the TAU campus. The Software Engineering is the building that is clipped by the right-edge of the map image - in the English map it is listed as the "Computer and Software Engineering" building.